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Brian Robertson, currently group risk officer, will be in charge of the group's operations in the UK and continental Europe.
Joe Garner will head the UK's retail and business banking divisions.
The appointments will take effect next week. Current UK boss Paul Thurston will take up a new role in Hong Kong.
He has been promoted to the newly-created post of chief executive of retail banking and wealth management.
In September, HSBC announced changes to the group's boardroom, with Stuart Gulliver set to replace Michael Geoghegan as chief executive next year.